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The Silicon Review Asia

Scientists find new Technique to Synthesise Products similar to Cannabis

Scientists find new Technique to Synthesise Products similar to Cannabis

A team of scientists from the National Chemical Laboratory, Pune has successfully synthesized two chemicals which are found in cannabis.  The two cannabinoids are Columbamide D and Serinolamide A. Cannabinoid is the chemical present in Cannabis. Earlier, the two compounds have been isolated from marine algae found in the belt of Malaysia and Papua and New Guinea.

But, there are limitations on the commercial use of the products. The team of scientist has synthesized the two chemical compounds in a laboratory by using a chemical method.

The chemical inside cannabis gets activated due to a biological system which is present inside the body. The system is known as “Endo-cannabinoid system”.  The system binds the action through a set of neurotransmitters called Endo-cannabinoids. It regulates many functions such as mood, memory, pain, appetite.

The scientists used a common intermediate, (R)-7, during the synthesizing process of Columbamide D and Serinolamide A. The common intermediate was derived from the chemical reactions which were carried out on commercially available chemical, (R)-benzyl glycidyl ether (R)-3.

Upon completing the synthesis process for the common intermediate, Columbamide D and Serinolamide A were synthesized by using different methods.

Even though earlier, studies have shown that there are possibilities of synthesizing cannabinoids chemically, but the scientists stated that the new technique is much effective and require fewer steps. The results obtained under the new technique were 62 percent for Columbamide D and 66 percent for Serinolamide A


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